1.1M XNAS Volume
XNAS 18 Mar, 2025 4:01 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 1.01 per share. | 19 Feb 2025 | 23,774 | 1,086,901 (0%) | 0% | 1.0 | 24,012 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 1.01 per share. | 19 Feb 2025 | 10,300 | 316,604 (0%) | 0% | 1.0 | 10,403 | Common Stock |
| Mark Andrew Wilson | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 1.01 per share. | 19 Feb 2025 | 11,040 | 324,292 (0%) | 0% | 1.0 | 11,150 | Common Stock |
| R. Scott Greer | Director | 31 Dec 2024 | 120,000 | 120,000 | - | - | Stock Option | ||
| Robert B. Chess | Director | 31 Dec 2024 | 120,000 | 120,000 | - | - | Stock Option | ||
| Roy A. Whitfield | Director | 31 Dec 2024 | 120,000 | 120,000 | - | - | Stock Option | ||
| Jeffrey R. Ajer | Director | 31 Dec 2024 | 120,000 | 120,000 | - | - | Stock Option | ||
| Diana M. Brainard | Director | 31 Dec 2024 | 120,000 | 120,000 | - | - | Stock Option | ||
| Wilson Mark Andrew | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 0.89 per share. | 23 Dec 2024 | 16,560 | 335,332 (0%) | 0% | 0.9 | 14,738 | Common Stock |
| Mark Wilson Andrew | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 0.90 per share. | 23 Dec 2024 | 33,402 | 351,892 (0%) | 0% | 0.9 | 30,062 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 0.94 per share. | 19 Dec 2024 | 51,115 | 326,904 (0%) | 0% | 0.9 | 48,048 | Common Stock |
| Robin Howard W. | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 0.99 per share. | 17 Dec 2024 | 85,035 | 1,110,675 (0%) | 0% | 1.0 | 84,185 | Common Stock |
| W. Howard Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 1.01 per share. | 17 Dec 2024 | 46,995 | 1,195,710 (0%) | 0% | 1.0 | 47,465 | Common Stock |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2024 | 410,625 | 1,242,705 (0%) | 0% | 0 | Common Stock | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2024 | 1,300,000 | 1,300,000 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2024 | 821,250 | 821,250 | - | - | Stock Option | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2024 | 375,000 | 375,000 | - | - | Stock Option | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2024 | 270,000 | 270,000 | - | - | Stock Option | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2024 | 135,000 | 378,019 (0%) | 0% | 0 | Common Stock | |
| Mark Andrew Wilson | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2024 | 325,000 | 325,000 | - | - | Stock Option | |
| Mark Andrew Wilson | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2024 | 331,875 | 331,875 | - | - | Stock Option | |
| Mark Andrew Wilson | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2024 | 165,938 | 385,294 (0%) | 0% | 0 | Common Stock | |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 1.01 per share. | 19 Nov 2024 | 16,278 | 832,080 (0%) | 0% | 1.0 | 16,441 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 1.01 per share. | 19 Nov 2024 | 7,785 | 243,019 (0%) | 0% | 1.0 | 7,863 | Common Stock |
| Mark Andrew Wilson | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 1.01 per share. | 19 Nov 2024 | 6,407 | 218,856 (0%) | 0% | 1.0 | 6,471 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 1.28 per share. | 19 Aug 2024 | 14,881 | 848,358 (0%) | 0% | 1.3 | 19,048 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 1.28 per share. | 19 Aug 2024 | 6,866 | 250,804 (0%) | 0% | 1.3 | 8,788 | Common Stock |
| Mark Andrew Wilson | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 1.28 per share. | 19 Aug 2024 | 5,651 | 225,263 (0%) | 0% | 1.3 | 7,233 | Common Stock |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 1.20 per share. | 14 Jun 2024 | 19,500 | 255,273 (0%) | 0% | 1.2 | 23,400 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 1.75 per share. | 17 May 2024 | 16,650 | 863,239 (0%) | 0% | 1.8 | 29,138 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 1.75 per share. | 17 May 2024 | 7,355 | 257,670 (0%) | 0% | 1.7 | 12,871 | Common Stock |
| Mark Andrew Wilson | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 1.75 per share. | 17 May 2024 | 6,260 | 230,414 (0%) | 0% | 1.8 | 10,955 | Common Stock |
| Wilson Andrew Mark | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 0.68 per share. | 20 Feb 2024 | 7,606 | 236,674 (0%) | 0% | 0.7 | 5,172 | Common Stock |
| Zalevsky Jonathan | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 0.68 per share. | 20 Feb 2024 | 9,014 | 265,025 (0%) | 0% | 0.7 | 6,130 | Common Stock |
| Robin W. Howard | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 0.68 per share. | 20 Feb 2024 | 20,033 | 879,889 (0%) | 0% | 0.7 | 13,622 | Common Stock |
| Andrew Wilson Mark | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2023 | 325,000 | 325,000 | - | - | Stock Option | |
| Robin Howard W. | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2023 | 1,300,000 | 1,300,000 | - | - | Stock Option | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2023 | 250,000 | 250,000 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 0.78 per share. | 16 Aug 2023 | 19,998 | 919,799 (0%) | 0% | 0.8 | 15,598 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 0.78 per share. | 16 Aug 2023 | 9,703 | 283,685 (0%) | 0% | 0.8 | 7,568 | Common Stock |
| Mark Andrew Wilson | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 0.78 per share. | 16 Aug 2023 | 7,221 | 250,959 (0%) | 0% | 0.8 | 5,632 | Common Stock |
| Roy A. Whitfield | Director | Sale of securities on an exchange or to another person at price $ 0.57 per share. | 14 Jun 2023 | 30,000 | 216,250 (0%) | 0% | 0.6 | 17,100 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 0.72 per share. | 16 May 2023 | 20,361 | 939,797 (0%) | 0% | 0.7 | 14,660 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 0.72 per share. | 16 May 2023 | 9,791 | 293,388 (0%) | 0% | 0.7 | 7,050 | Common Stock |
| Mark Andrew Wilson | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 0.72 per share. | 16 May 2023 | 7,543 | 257,680 (0%) | 0% | 0.7 | 5,431 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 3.00 per share. | 16 Feb 2023 | 19,635 | 960,158 (0%) | 0% | 3 | 58,905 | Common Stock |
| Jillian B. Thomsen | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 3.00 per share. | 16 Feb 2023 | 10,267 | 313,497 (0%) | 0% | 3 | 30,801 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 3.00 per share. | 16 Feb 2023 | 10,484 | 303,179 (0%) | 0% | 3 | 31,452 | Common Stock |
| Mark Andrew Wilson | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 3.00 per share. | 16 Feb 2023 | 8,275 | 265,223 (0%) | 0% | 3 | 24,825 | Common Stock |
| Jeffrey R. Ajer | Director | Sale of securities on an exchange or to another person at price $ 3.16 per share. | 23 Sep 2022 | 4,198 | 38,512 (0%) | 0% | 3.2 | 13,266 | Common Stock |
| Myriam J. Curet | Director | Sale of securities on an exchange or to another person at price $ 3.16 per share. | 23 Sep 2022 | 4,198 | 31,777 (0%) | 0% | 3.2 | 13,266 | Common Stock |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 3.19 per share. | 22 Sep 2022 | 5,100 | 228,179 (0%) | 0% | 3.2 | 16,269 | Common Stock |
| Karin Eastham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 20,400 | 20,400 | - | - | Stock Option | |
| Karin Eastham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 10,200 | 23,233 (0%) | 0% | 0 | Common Stock | |
| R. Scott Greer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 10,200 | 303,574 (0%) | 0% | 0 | Common Stock | |
| R. Scott Greer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 20,400 | 20,400 | - | - | Stock Option | |
| Robert B. Chess | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 10,200 | 233,279 (0%) | 0% | 0 | Common Stock | |
| Robert B. Chess | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 20,400 | 20,400 | - | - | Stock Option | |
| Roy A. Whitfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 20,400 | 20,400 | - | - | Stock Option | |
| Roy A. Whitfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 10,200 | 246,250 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 20,400 | 20,400 | - | - | Stock Option | |
| Jeffrey R. Ajer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 10,200 | 42,710 (0%) | 0% | 0 | Common Stock | |
| Myriam J. Curet | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 10,200 | 35,975 (0%) | 0% | 0 | Common Stock | |
| Myriam J. Curet | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 20,400 | 20,400 | - | - | Stock Option | |
| Diana Brainard | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 20,400 | 20,400 | - | - | Stock Option | |
| Diana Brainard | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 10,200 | 28,560 (0%) | 0% | 0 | Common Stock | |
| Karin Eastham | Director | Sale of securities on an exchange or to another person at price $ 3.61 per share. | 13 Sep 2022 | 21,267 | 13,033 (0%) | 0% | 3.6 | 76,774 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 4.65 per share. | 18 Aug 2022 | 73,716 | 327,123 (0%) | 0% | 4.6 | 342,779 | Common Stock |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2022 | 410,625 | 1,031,566 (0%) | 0% | 0 | Common Stock | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2022 | 821,250 | 821,250 | - | - | Common Stock | |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 4.76 per share. | 15 Aug 2022 | 13,759 | 1,017,807 (0%) | 0% | 4.8 | 65,493 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2022 | 165,938 | 336,865 (0%) | 0% | 0 | Common Stock | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2022 | 331,875 | 331,875 | - | - | Common Stock | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 4.76 per share. | 15 Aug 2022 | 2,006 | 334,859 (0%) | 0% | 4.8 | 9,549 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 4.76 per share. | 15 Aug 2022 | 10,560 | 400,839 (0%) | 0% | 4.8 | 50,266 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2022 | 270,000 | 270,000 | - | - | Common Stock | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2022 | 135,000 | 411,399 (0%) | 0% | 0 | Common Stock | |
| Mark Andrew Wilson | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2022 | 331,875 | 331,875 | - | - | Common Stock | |
| Mark Andrew Wilson | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2022 | 165,938 | 284,377 (0%) | 0% | 0 | Common Stock | |
| Mark Andrew Wilson | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 4.76 per share. | 15 Aug 2022 | 3,189 | 281,188 (0%) | 0% | 4.8 | 15,180 | Common Stock |
| John P. Northcott | SVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 3.95 per share. | 16 May 2022 | 4,592 | 223,210 (0%) | 0% | 3.9 | 18,138 | Common Stock |
| Mark Andrew Wilson | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 3.95 per share. | 16 May 2022 | 3,136 | 117,939 (0%) | 0% | 3.9 | 12,387 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2022 | 28,750 | 330,353 (0%) | 0% | 0 | Common Stock | |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 3.95 per share. | 15 May 2022 | 17,448 | 312,905 (0%) | 0% | 4.0 | 68,920 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 3.95 per share. | 15 May 2022 | 36,529 | 620,941 (0%) | 0% | 4.0 | 144,290 | Common Stock |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2022 | 68,450 | 657,470 (0%) | 0% | 0 | Common Stock | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2022 | 10,950 | 176,268 (0%) | 0% | 0 | Common Stock | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 3.95 per share. | 15 May 2022 | 5,841 | 170,427 (0%) | 0% | 4.0 | 23,072 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 3.95 per share. | 15 May 2022 | 21,673 | 276,399 (0%) | 0% | 3.9 | 85,608 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2022 | 23,950 | 298,072 (0%) | 0% | 0 | Common Stock | |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 10.95 per share. | 16 Feb 2022 | 7,579 | 301,603 (0%) | 0% | 10.9 | 82,990 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 10.95 per share. | 16 Feb 2022 | 12,480 | 589,020 (0%) | 0% | 11.0 | 136,656 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 10.95 per share. | 16 Feb 2022 | 2,363 | 165,318 (0%) | 0% | 11.0 | 25,875 | Common Stock |
| John P. Northcott | SVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 10.95 per share. | 16 Feb 2022 | 4,852 | 227,802 (0%) | 0% | 10.9 | 53,129 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 10.95 per share. | 16 Feb 2022 | 10,912 | 274,122 (0%) | 0% | 10.9 | 119,486 | Common Stock |
| Mark Andrew Wilson | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 10.95 per share. | 16 Feb 2022 | 3,661 | 121,075 (0%) | 0% | 11.0 | 40,088 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 94,000 | 94,000 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 52,950 | 309,182 (0%) | 0% | 0 | Common Stock | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 126,050 | 601,500 (0%) | 0% | 0 | Common Stock | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 223,750 | 223,750 | - | - | Stock Option | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 37,600 | 37,600 | - | - | Stock Option | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 21,200 | 167,681 (0%) | 0% | 0 | Common Stock | |
| John P. Northcott | SVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 67,150 | 67,150 | - | - | Stock Option | |
| John P. Northcott | SVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 37,800 | 232,654 (0%) | 0% | 0 | Common Stock | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 52,950 | 285,034 (0%) | 0% | 0 | Common Stock | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 94,000 | 94,000 | - | - | Stock Option | |
| Mark Andrew Wilson | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 67,150 | 67,150 | - | - | Stock Option | |
| Mark Andrew Wilson | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2021 | 37,800 | 124,736 (0%) | 0% | 0 | Common Stock | |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 13.16 per share. | 16 Nov 2021 | 21,149 | 259,682 (0%) | 0% | 13.2 | 278,321 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 12.69 per share. | 16 Nov 2021 | 3,000 | 256,682 (0%) | 0% | 12.7 | 38,070 | Common Stock |
| John P. Northcott | SVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 13.16 per share. | 16 Nov 2021 | 6,061 | 194,854 (0%) | 0% | 13.2 | 79,763 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 13.16 per share. | 15 Nov 2021 | 42,773 | 475,450 (0%) | 0% | 13.2 | 562,893 | Common Stock |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2021 | 94,100 | 518,223 (0%) | 0% | 0 | Common Stock | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 13.16 per share. | 15 Nov 2021 | 6,741 | 145,981 (0%) | 0% | 13.2 | 88,712 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2021 | 14,900 | 152,722 (0%) | 0% | 0 | Common Stock | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2021 | 40,150 | 252,953 (0%) | 0% | 0 | Common Stock | |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 13.16 per share. | 15 Nov 2021 | 20,869 | 232,084 (0%) | 0% | 13.2 | 274,636 | Common Stock |
| Mark Andrew Wilson | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 13.16 per share. | 15 Nov 2021 | 6,564 | 86,436 (0%) | 0% | 13.2 | 86,382 | Common Stock |
| Mark Andrew Wilson | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Nov 2021 | 20,100 | 93,000 (0%) | 0% | 0 | Common Stock | |
| Diana Brainard | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Nov 2021 | 36,720 | 36,720 | - | - | Stock Option | |
| Diana Brainard | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Nov 2021 | 18,360 | 18,360 (0%) | 0% | 0 | Common Stock | |
| R. Scott Greer | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Nov 2021 | 12,500 | 0 | - | - | Stock Option | |
| R. Scott Greer | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.80 per share. | 09 Nov 2021 | 12,500 | 293,374 (0%) | 0% | 12.8 | 160,000 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Oct 2021 | 71,550 | 71,550 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Oct 2021 | 167,650 | 167,650 | - | - | Stock Option | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Oct 2021 | 26,600 | 26,600 | - | - | Stock Option | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Oct 2021 | 71,550 | 71,550 | - | - | Stock Option | |
| Mark Andrew Wilson | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Oct 2021 | 35,800 | 35,800 | - | - | Stock Option | |
| Karin Eastham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2021 | 10,200 | 34,300 (0%) | 0% | 0 | Common Stock | |
| Karin Eastham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2021 | 20,400 | 20,400 | - | - | Stock Option | |
| R. Scott Greer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2021 | 20,400 | 20,400 | - | - | Stock Option | |
| R. Scott Greer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2021 | 10,200 | 280,874 (0%) | 0% | 0 | Common Stock | |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 17.94 per share. | 22 Sep 2021 | 4,600 | 279,873 (0%) | 0% | 17.9 | 82,524 | Common Stock |
| Robert B. Chess | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2021 | 20,400 | 20,400 | - | - | Stock Option | |
| Robert B. Chess | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2021 | 10,200 | 284,473 (0%) | 0% | 0 | Common Stock | |
| Roy A. Whitfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2021 | 10,200 | 236,050 (0%) | 0% | 0 | Common Stock | |
| Roy A. Whitfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2021 | 20,400 | 20,400 | - | - | Stock Option | |
| Jeffrey R. Ajer | Director | Sale of securities on an exchange or to another person at price $ 17.78 per share. | 22 Sep 2021 | 3,665 | 32,510 (0%) | 0% | 17.8 | 65,164 | Common Stock |
| Jeffrey R. Ajer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2021 | 20,400 | 20,400 | - | - | Stock Option | |
| Jeffrey R. Ajer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2021 | 10,200 | 36,175 (0%) | 0% | 0 | Common Stock | |
| Myriam J. Curet | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2021 | 20,400 | 20,400 | - | - | Stock Option | |
| Myriam J. Curet | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2021 | 10,200 | 29,440 (0%) | 0% | 0 | Common Stock | |
| Myriam J. Curet | Director | Sale of securities on an exchange or to another person at price $ 17.78 per share. | 22 Sep 2021 | 3,665 | 25,775 (0%) | 0% | 17.8 | 65,164 | Common Stock |
| Roy A. Whitfield | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.80 per share. | 16 Sep 2021 | 40,000 | 225,850 (0%) | 0% | 13.8 | 552,000 | Common Stock |
| Roy A. Whitfield | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2021 | 40,000 | 0 | - | - | Stock Option | |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 16.00 per share. | 08 Sep 2021 | 8,000 | 274,273 (0%) | 0% | 16 | 128,000 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2021 | 10,279 | 0 | - | - | Common Stock | |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2021 | 8,000 | 10,279 | - | - | Common Stock | |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 16.02 per share. | 08 Sep 2021 | 10,279 | 274,273 (0%) | 0% | 16.0 | 164,670 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.80 per share. | 08 Sep 2021 | 10,279 | 284,552 (0%) | 0% | 13.8 | 141,850 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.80 per share. | 08 Sep 2021 | 8,000 | 282,273 (0%) | 0% | 13.8 | 110,400 | Common Stock |
| R. Scott Greer | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.70 per share. | 31 Aug 2021 | 45,000 | 270,674 (0%) | 0% | 12.7 | 571,500 | Common Stock |
| R. Scott Greer | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Aug 2021 | 45,000 | 0 | - | - | Stock Option | |
| Robert B. Chess | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Aug 2021 | 2,100 | 2,100 (0%) | 0% | 0 | Common Stock | |
| Robert B. Chess | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Aug 2021 | 6,300 | 274,273 (0%) | 0% | 0 | Common Stock | |
| Robert B. Chess | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Aug 2021 | 2,100 | 2,100 (0%) | 0% | 0 | Common Stock | |
| Robert B. Chess | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 24 Aug 2021 | 2,100 | 2,100 (0%) | 0% | 0 | Common Stock | |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 13.56 per share. | 16 Aug 2021 | 3,000 | 240,231 (0%) | 0% | 13.6 | 40,680 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 13.83 per share. | 16 Aug 2021 | 7,867 | 243,231 (0%) | 0% | 13.8 | 108,801 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 13.83 per share. | 16 Aug 2021 | 11,515 | 424,123 (0%) | 0% | 13.8 | 159,252 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 13.83 per share. | 16 Aug 2021 | 13,339 | 137,822 (0%) | 0% | 13.8 | 184,478 | Common Stock |
| John P. Northcott | SVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 13.83 per share. | 16 Aug 2021 | 6,192 | 200,915 (0%) | 0% | 13.8 | 85,635 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 13.83 per share. | 16 Aug 2021 | 7,662 | 212,803 (0%) | 0% | 13.8 | 105,965 | Common Stock |
| Mark Andrew Wilson | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 13.83 per share. | 16 Aug 2021 | 1,910 | 72,900 (0%) | 0% | 13.8 | 26,415 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2021 | 91 | 18,279 | - | - | Stock Option | |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2021 | 3,524 | 18,370 | - | - | Stock Option | |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2021 | 2,106 | 21,894 | - | - | Stock Option | |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 16.80 per share. | 20 Jul 2021 | 91 | 280,573 (0%) | 0% | 16.8 | 1,529 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.80 per share. | 20 Jul 2021 | 91 | 280,664 (0%) | 0% | 13.8 | 1,256 | Common Stock |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 16.81 per share. | 20 Jul 2021 | 3,524 | 280,573 (0%) | 0% | 16.8 | 59,238 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.80 per share. | 20 Jul 2021 | 3,524 | 284,097 (0%) | 0% | 13.8 | 48,631 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.80 per share. | 20 Jul 2021 | 2,106 | 282,679 (0%) | 0% | 13.8 | 29,063 | Common Stock |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 16.80 per share. | 20 Jul 2021 | 2,106 | 280,573 (0%) | 0% | 16.8 | 35,381 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 18.30 per share. | 17 May 2021 | 7,898 | 251,098 (0%) | 0% | 18.3 | 144,533 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 18.30 per share. | 17 May 2021 | 11,560 | 435,638 (0%) | 0% | 18.3 | 211,548 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 18.30 per share. | 17 May 2021 | 13,391 | 151,161 (0%) | 0% | 18.3 | 245,055 | Common Stock |
| John P. Northcott | SVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 18.30 per share. | 17 May 2021 | 6,085 | 207,107 (0%) | 0% | 18.3 | 111,356 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 18.30 per share. | 17 May 2021 | 31,111 | 235,065 (0%) | 0% | 18.3 | 569,331 | Common Stock |
| Mark Andrew Wilson | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 18.30 per share. | 17 May 2021 | 1,917 | 74,810 (0%) | 0% | 18.3 | 35,081 | Common Stock |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 19.34 per share. | 12 May 2021 | 8,000 | 280,573 (0%) | 0% | 19.3 | 154,720 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 May 2021 | 8,000 | 24,000 | - | - | Stock Option | |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.80 per share. | 12 May 2021 | 8,000 | 288,573 (0%) | 0% | 13.8 | 110,400 | Common Stock |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 18.98 per share. | 14 Apr 2021 | 8,000 | 280,573 (0%) | 0% | 19.0 | 151,840 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Apr 2021 | 8,000 | 32,000 | - | - | Stock Option | |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.80 per share. | 14 Apr 2021 | 8,000 | 288,573 (0%) | 0% | 13.8 | 110,400 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 22.37 per share. | 16 Feb 2021 | 7,977 | 258,996 (0%) | 0% | 22.4 | 178,445 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 22.37 per share. | 16 Feb 2021 | 11,495 | 447,198 (0%) | 0% | 22.4 | 257,143 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 22.37 per share. | 16 Feb 2021 | 11,705 | 164,552 (0%) | 0% | 22.4 | 261,841 | Common Stock |
| John P. Northcott | SVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 22.37 per share. | 16 Feb 2021 | 15,358 | 213,192 (0%) | 0% | 22.4 | 343,558 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 22.37 per share. | 16 Feb 2021 | 24,141 | 266,176 (0%) | 0% | 22.4 | 540,034 | Common Stock |
| Mark Andrew Wilson | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 22.37 per share. | 16 Feb 2021 | 2,173 | 76,727 (0%) | 0% | 22.4 | 48,610 | Common Stock |
| Mark Andrew Wilson | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 19.45 per share. | 03 Feb 2021 | 5,344 | 78,900 (0%) | 0% | 19.5 | 103,941 | Common Stock |
| Mark Andrew Wilson | SVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2021 | 5,344 | 0 | - | - | Stock Option | |
| Mark Andrew Wilson | SVP & General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 03 Feb 2021 | 5,344 | 84,244 (0%) | 0% | 8.8 | 47,027 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 02 Feb 2021 | 25,000 | 291,973 (0%) | 0% | 8.8 | 220,000 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2021 | 50,000 | 0 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2021 | 25,000 | 50,000 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2021 | 25,000 | 0 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2021 | 50,000 | 25,000 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 19.81 per share. | 02 Feb 2021 | 50,000 | 266,973 (0%) | 0% | 19.8 | 990,500 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 02 Feb 2021 | 50,000 | 316,973 (0%) | 0% | 8.8 | 440,000 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 19.61 per share. | 02 Feb 2021 | 50,000 | 266,973 (0%) | 0% | 19.6 | 980,500 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 02 Feb 2021 | 25,000 | 316,973 (0%) | 0% | 8.8 | 220,000 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 21.66 per share. | 02 Feb 2021 | 1,933 | 266,973 (0%) | 0% | 21.7 | 41,869 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 20.96 per share. | 02 Feb 2021 | 6,932 | 268,906 (0%) | 0% | 21.0 | 145,295 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 19.97 per share. | 02 Feb 2021 | 41,135 | 275,838 (0%) | 0% | 20.0 | 821,466 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 02 Feb 2021 | 50,000 | 316,973 (0%) | 0% | 8.8 | 440,000 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 02 Feb 2021 | 150,000 | 608,693 (0%) | 0% | 8.8 | 1,320,000 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2021 | 150,000 | 0 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2021 | 75,000 | 150,000 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2021 | 75,000 | 0 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Feb 2021 | 150,000 | 75,000 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 20.58 per share. | 02 Feb 2021 | 58,137 | 458,693 (0%) | 0% | 20.6 | 1,196,459 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 20.10 per share. | 02 Feb 2021 | 91,863 | 516,830 (0%) | 0% | 20.1 | 1,846,446 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 02 Feb 2021 | 150,000 | 608,693 (0%) | 0% | 8.8 | 1,320,000 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 19.72 per share. | 02 Feb 2021 | 150,000 | 458,693 (0%) | 0% | 19.7 | 2,958,000 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 02 Feb 2021 | 75,000 | 608,693 (0%) | 0% | 8.8 | 660,000 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 02 Feb 2021 | 75,000 | 533,693 (0%) | 0% | 8.8 | 660,000 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 21.59 per share. | 02 Feb 2021 | 600 | 458,693 (0%) | 0% | 21.6 | 12,954 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 20.84 per share. | 02 Feb 2021 | 9,900 | 459,293 (0%) | 0% | 20.8 | 206,316 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 19.69 per share. | 02 Feb 2021 | 139,500 | 469,193 (0%) | 0% | 19.7 | 2,746,755 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 28 Jan 2021 | 37,500 | 213,757 (0%) | 0% | 8.8 | 330,000 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jan 2021 | 37,500 | 0 | - | - | Stock Option | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jan 2021 | 37,500 | 0 | - | - | Stock Option | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 18.62 per share. | 28 Jan 2021 | 75,000 | 176,257 (0%) | 0% | 18.6 | 1,396,500 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 8.80 per share. | 28 Jan 2021 | 37,500 | 251,257 (0%) | 0% | 8.8 | 330,000 | Common Stock |
| R. Scott Greer | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.80 per share. | 05 Jan 2021 | 40,000 | 225,674 (0%) | 0% | 13.8 | 552,000 | Common Stock |
| R. Scott Greer | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2021 | 40,000 | 0 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2020 | 71,500 | 71,500 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2020 | 40,000 | 266,973 (0%) | 0% | 0 | Common Stock | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2020 | 106,650 | 458,693 (0%) | 0% | 0 | Common Stock | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2020 | 190,650 | 190,650 | - | - | Stock Option | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2020 | 28,600 | 28,600 | - | - | Stock Option | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2020 | 16,000 | 176,257 (0%) | 0% | 0 | Common Stock | |
| John P. Northcott | SVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2020 | 51,000 | 51,000 | - | - | Stock Option | |
| John P. Northcott | SVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2020 | 28,550 | 228,550 (0%) | 0% | 0 | Common Stock | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2020 | 71,500 | 71,500 | - | - | Stock Option | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2020 | 40,000 | 290,317 (0%) | 0% | 0 | Common Stock | |
| Mark Andrew Wilson | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2020 | 28,550 | 78,900 (0%) | 0% | 0 | Common Stock | |
| Mark Andrew Wilson | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Dec 2020 | 51,000 | 51,000 | - | - | Stock Option | |
| Myriam J. Curet | Director | Sale of securities on an exchange or to another person at price $ 17.82 per share. | 15 Dec 2020 | 1,560 | 19,240 (0%) | 0% | 17.8 | 27,799 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 16.40 per share. | 23 Nov 2020 | 16,380 | 250,317 (0%) | 0% | 16.4 | 268,632 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 16.93 per share. | 16 Nov 2020 | 8,276 | 226,973 (0%) | 0% | 16.9 | 140,113 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 16.93 per share. | 16 Nov 2020 | 11,975 | 352,043 (0%) | 0% | 16.9 | 202,737 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 16.93 per share. | 16 Nov 2020 | 11,976 | 159,757 (0%) | 0% | 16.9 | 202,754 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 16.93 per share. | 16 Nov 2020 | 29,618 | 266,697 (0%) | 0% | 16.9 | 501,433 | Common Stock |
| Mark Andrew Wilson | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 16.93 per share. | 16 Nov 2020 | 1,539 | 49,850 (0%) | 0% | 16.9 | 26,055 | Common Stock |
| Jeffrey R. Ajer | Director | Sale of securities on an exchange or to another person at price $ 17.25 per share. | 28 Sep 2020 | 3,250 | 25,975 (0%) | 0% | 17.3 | 56,063 | Common Stock |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 17.75 per share. | 25 Sep 2020 | 5,500 | 280,573 (0%) | 0% | 17.8 | 97,625 | Common Stock |
| Karin Eastham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 9,100 | 24,100 (0%) | 0% | 0 | Common Stock | |
| Karin Eastham | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 18,200 | 18,200 | - | - | Stock Option | |
| R. Scott Greer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 18,200 | 18,200 | - | - | Stock Option | |
| R. Scott Greer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 9,100 | 185,674 (0%) | 0% | 0 | Common Stock | |
| Robert B. Chess | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 18,200 | 18,200 | - | - | Stock Option | |
| Robert B. Chess | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 9,100 | 286,073 (0%) | 0% | 0 | Common Stock | |
| Roy A. Whitfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 18,200 | 18,200 | - | - | Stock Option | |
| Roy A. Whitfield | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 9,100 | 237,350 (0%) | 0% | 0 | Common Stock | |
| Lutz Lingnau | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 18,200 | 18,200 | - | - | Stock Option | |
| Lutz Lingnau | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 9,100 | 35,800 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 9,100 | 29,225 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 18,200 | 18,200 | - | - | Stock Option | |
| Myriam J. Curet | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 9,100 | 20,800 (0%) | 0% | 0 | Common Stock | |
| Myriam J. Curet | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 18,200 | 18,200 | - | - | Stock Option | |
| Myriam J. Curet | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 18,200 | 18,200 | - | - | Stock Option | |
| Myriam J. Curet | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 22 Sep 2020 | 9,100 | 20,800 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | Director | Sale of securities on an exchange or to another person at price $ 19.74 per share. | 21 Sep 2020 | 2,250 | 20,125 (0%) | 0% | 19.7 | 44,415 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 19.96 per share. | 17 Sep 2020 | 2,000 | 235,249 (0%) | 0% | 20.0 | 39,920 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.24 per share. | 08 Sep 2020 | 8,000 | 284,973 (0%) | 0% | 9.2 | 73,920 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2020 | 8,000 | 0 | - | - | Stock Option | |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 18.53 per share. | 08 Sep 2020 | 8,000 | 276,973 (0%) | 0% | 18.5 | 148,240 | Common Stock |
| Roy A. Whitfield | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.24 per share. | 04 Sep 2020 | 30,000 | 228,250 (0%) | 0% | 9.2 | 277,200 | Common Stock |
| Roy A. Whitfield | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Sep 2020 | 30,000 | 0 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 19.68 per share. | 17 Aug 2020 | 2,000 | 237,249 (0%) | 0% | 19.7 | 39,360 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 19.67 per share. | 17 Aug 2020 | 6,245 | 239,249 (0%) | 0% | 19.7 | 122,839 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 19.67 per share. | 17 Aug 2020 | 11,885 | 364,018 (0%) | 0% | 19.7 | 233,778 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 19.67 per share. | 17 Aug 2020 | 1,367 | 171,733 (0%) | 0% | 19.7 | 26,889 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 19.67 per share. | 17 Aug 2020 | 26,200 | 296,315 (0%) | 0% | 19.7 | 515,354 | Common Stock |
| Mark Andrew Wilson | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 19.67 per share. | 17 Aug 2020 | 1,529 | 51,389 (0%) | 0% | 19.7 | 30,075 | Common Stock |
| R. Scott Greer | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.24 per share. | 09 Jul 2020 | 40,000 | 191,583 (0%) | 0% | 9.2 | 369,600 | Common Stock |
| R. Scott Greer | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jul 2020 | 40,000 | 0 | - | - | Stock Option | |
| R. Scott Greer | Director | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 09 Jul 2020 | 15,009 | 176,574 (0%) | 0% | 25 | 375,225 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.24 per share. | 08 Jul 2020 | 8,000 | 284,973 (0%) | 0% | 9.2 | 73,920 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jul 2020 | 8,000 | 8,000 | - | - | Stock Option | |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 24.58 per share. | 08 Jul 2020 | 8,000 | 276,973 (0%) | 0% | 24.6 | 196,640 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 22.62 per share. | 18 May 2020 | 2,000 | 245,494 (0%) | 0% | 22.6 | 45,240 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 22.51 per share. | 18 May 2020 | 5,727 | 247,494 (0%) | 0% | 22.5 | 128,915 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 22.51 per share. | 18 May 2020 | 8,968 | 375,903 (0%) | 0% | 22.5 | 201,870 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 22.51 per share. | 18 May 2020 | 1,367 | 172,719 (0%) | 0% | 22.5 | 30,771 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 22.51 per share. | 18 May 2020 | 4,558 | 322,515 (0%) | 0% | 22.5 | 102,601 | Common Stock |
| Mark Andrew Wilson | SVP & General Counsel | Sale of securities on an exchange or to another person at price $ 22.51 per share. | 18 May 2020 | 1,529 | 52,418 (0%) | 0% | 22.5 | 34,418 | Common Stock |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 18.36 per share. | 15 Apr 2020 | 7,803 | 277,170 (0%) | 0% | 18.4 | 143,263 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2020 | 8,000 | 16,000 | - | - | Stock Option | |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 19.02 per share. | 15 Apr 2020 | 197 | 276,973 (0%) | 0% | 19.0 | 3,747 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.24 per share. | 15 Apr 2020 | 8,000 | 284,973 (0%) | 0% | 9.2 | 73,920 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.24 per share. | 11 Mar 2020 | 8,000 | 284,973 (0%) | 0% | 9.2 | 73,920 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2020 | 8,000 | 24,000 | - | - | Stock Option | |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 17.41 per share. | 11 Mar 2020 | 1,200 | 276,973 (0%) | 0% | 17.4 | 20,892 | Common Stock |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 16.68 per share. | 11 Mar 2020 | 6,800 | 278,173 (0%) | 0% | 16.7 | 113,424 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 22.35 per share. | 18 Feb 2020 | 5,938 | 253,221 (0%) | 0% | 22.3 | 132,714 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 22.35 per share. | 18 Feb 2020 | 8,448 | 384,871 (0%) | 0% | 22.4 | 188,813 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 22.35 per share. | 18 Feb 2020 | 1,394 | 174,086 (0%) | 0% | 22.4 | 31,156 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 22.35 per share. | 18 Feb 2020 | 4,774 | 327,073 (0%) | 0% | 22.4 | 106,699 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.24 per share. | 12 Feb 2020 | 8,000 | 284,973 (0%) | 0% | 9.2 | 73,920 | Common Stock |
| Robert B. Chess | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Feb 2020 | 8,000 | 32,000 | - | - | Stock Option | |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 23.72 per share. | 12 Feb 2020 | 3,599 | 276,973 (0%) | 0% | 23.7 | 85,368 | Common Stock |
| Robert B. Chess | Director | Sale of securities on an exchange or to another person at price $ 23.32 per share. | 12 Feb 2020 | 4,401 | 280,572 (0%) | 0% | 23.3 | 102,631 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Feb 2020 | 37,500 | 0 | - | - | Stock Option | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 06 Feb 2020 | 37,500 | 212,980 (0%) | 0% | 7.2 | 270,375 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 22.78 per share. | 06 Feb 2020 | 37,500 | 175,480 (0%) | 0% | 22.8 | 854,250 | Common Stock |
| Roy A. Whitfield | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.24 per share. | 18 Dec 2019 | 10,000 | 198,250 (0%) | 0% | 9.2 | 92,400 | Common Stock |
| Roy A. Whitfield | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Dec 2019 | 10,000 | 30,000 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 29,000 | 29,000 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 71,550 | 71,550 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 40,150 | 259,159 (0%) | 0% | 0 | Common Stock | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 44,600 | 44,600 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 167,650 | 167,650 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 94,100 | 393,319 (0%) | 0% | 0 | Common Stock | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 11,800 | 11,800 | - | - | Stock Option | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 14,900 | 175,480 (0%) | 0% | 0 | Common Stock | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 26,600 | 26,600 | - | - | Stock Option | |
| Myriam J. Curet | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 11,700 | 11,700 (0%) | 0% | 0 | Common Stock | |
| Myriam J. Curet | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 23,400 | 23,400 | - | - | Stock Option | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 20,100 | 20,100 | - | - | Stock Option | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 40,150 | 331,847 (0%) | 0% | 0 | Common Stock | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2019 | 71,550 | 71,550 | - | - | Stock Option | |
| John P. Northcott | SVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2019 | 200,000 | 200,000 (0%) | 0% | 0 | Common Stock | |
| John P. Northcott | SVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Dec 2019 | 200,000 | 200,000 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 17.97 per share. | 18 Nov 2019 | 8,863 | 219,009 (0%) | 0% | 18.0 | 159,268 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 17.97 per share. | 18 Nov 2019 | 13,556 | 299,219 (0%) | 0% | 18.0 | 243,601 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 17.97 per share. | 18 Nov 2019 | 2,713 | 160,441 (0%) | 0% | 18.0 | 48,753 | Common Stock |
| Jonathan Zalevsky | Chief R&D Officer | Sale of securities on an exchange or to another person at price $ 17.97 per share. | 18 Nov 2019 | 3,960 | 291,697 (0%) | 0% | 18.0 | 71,161 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 19.79 per share. | 13 Nov 2019 | 25,000 | 227,872 (0%) | 0% | 19.8 | 494,750 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Nov 2019 | 25,000 | 0 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 13 Nov 2019 | 25,000 | 252,872 (0%) | 0% | 7.2 | 180,250 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Sale of securities on an exchange or to another person at price $ 15.83 per share. | 15 Oct 2019 | 25,000 | 227,872 (0%) | 0% | 15.8 | 395,750 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 15 Oct 2019 | 25,000 | 252,872 (0%) | 0% | 7.2 | 180,250 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2019 | 25,000 | 25,000 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 17.17 per share. | 15 Oct 2019 | 24,500 | 312,775 (0%) | 0% | 17.2 | 420,665 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2019 | 33,333 | 0 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2019 | 33,334 | 33,333 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Oct 2019 | 33,333 | 66,667 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 17.68 per share. | 15 Oct 2019 | 33,333 | 312,775 (0%) | 0% | 17.7 | 589,327 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 15 Oct 2019 | 33,333 | 346,108 (0%) | 0% | 7.2 | 240,331 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 17.48 per share. | 15 Oct 2019 | 33,334 | 312,775 (0%) | 0% | 17.5 | 582,678 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 15 Oct 2019 | 33,334 | 346,109 (0%) | 0% | 7.2 | 240,338 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 16.35 per share. | 15 Oct 2019 | 8,833 | 337,275 (0%) | 0% | 16.4 | 144,420 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 15 Oct 2019 | 33,333 | 346,108 (0%) | 0% | 7.2 | 240,331 | Common Stock |
| Gil M. Labrucherie | SVP, COO & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2019 | 150,000 | 150,000 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP, COO & CFO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2019 | 75,000 | 227,872 (0%) | 0% | 0 | Common Stock | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2019 | 150,000 | 150,000 | - | - | Stock Option | |
| Jonathan Zalevsky | Chief R&D Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2019 | 75,000 | 295,657 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | None | Sale of securities on an exchange or to another person at price $ 18.06 per share. | 30 Sep 2019 | 2,375 | 22,375 (0%) | 0% | 18.1 | 42,893 | Common Stock |
| Robert B. Chess | None | Sale of securities on an exchange or to another person at price $ 17.99 per share. | 27 Sep 2019 | 4,000 | 276,973 (0%) | 0% | 18.0 | 71,960 | Common Stock |
| Lutz Lingnau | None | Sale of securities on an exchange or to another person at price $ 17.84 per share. | 27 Sep 2019 | 3,000 | 26,700 (0%) | 0% | 17.8 | 53,520 | Common Stock |
| Karin Eastham | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2019 | 6,500 | 15,000 (0%) | 0% | 0 | Common Stock | |
| Karin Eastham | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2019 | 13,000 | 13,000 | - | - | Stock Option | |
| R. Scott Greer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2019 | 13,000 | 13,000 | - | - | Stock Option | |
| R. Scott Greer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2019 | 6,500 | 151,583 (0%) | 0% | 0 | Common Stock | |
| Robert B. Chess | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2019 | 6,500 | 280,973 (0%) | 0% | 0 | Common Stock | |
| Robert B. Chess | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2019 | 13,000 | 13,000 | - | - | Stock Option | |
| Roy A. Whitfield | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2019 | 6,500 | 188,250 (0%) | 0% | 0 | Common Stock | |
| Roy A. Whitfield | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2019 | 13,000 | 13,000 | - | - | Stock Option | |
| Lutz Lingnau | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2019 | 6,500 | 29,700 (0%) | 0% | 0 | Common Stock | |
| Lutz Lingnau | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2019 | 13,000 | 13,000 | - | - | Stock Option | |
| Jeffrey R. Ajer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2019 | 13,000 | 13,000 | - | - | Stock Option | |
| Jeffrey R. Ajer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 25 Sep 2019 | 6,500 | 24,750 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | None | Sale of securities on an exchange or to another person at price $ 20.24 per share. | 20 Sep 2019 | 2,250 | 18,250 (0%) | 0% | 20.2 | 45,540 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.52 per share. | 16 Sep 2019 | 25,000 | 152,872 (0%) | 0% | 20.5 | 513,000 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 16 Sep 2019 | 25,000 | 177,872 (0%) | 0% | 7.2 | 180,250 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Sep 2019 | 25,000 | 50,000 | - | - | Stock Option | |
| Stephen K. Doberstein | SVP & Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 17.28 per share. | 05 Sep 2019 | 15,000 | 107,668 (0%) | 0% | 17.3 | 259,200 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2019 | 30,000 | 57,500 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.31 per share. | 26 Aug 2019 | 30,000 | 152,872 (0%) | 0% | 16.3 | 489,300 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.31 per share. | 23 Aug 2019 | 30,000 | 312,775 (0%) | 0% | 16.3 | 489,300 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Aug 2019 | 30,000 | 195,000 | - | - | Common Stock | |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 16 Aug 2019 | 5,063 | 122,872 (0%) | 0% | 18.1 | 91,893 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 16 Aug 2019 | 12,551 | 282,775 (0%) | 0% | 18.2 | 227,801 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 16 Aug 2019 | 1,809 | 163,154 (0%) | 0% | 18.1 | 32,833 | Common Stock |
| John Nicholson | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 16 Aug 2019 | 3,819 | 162,759 (0%) | 0% | 18.2 | 69,315 | Common Stock |
| Stephen K. Doberstein | SVP & Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 18.15 per share. | 16 Aug 2019 | 3,245 | 92,668 (0%) | 0% | 18.2 | 58,897 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 17.79 per share. | 14 Aug 2019 | 25,000 | 127,935 (0%) | 0% | 17.8 | 444,750 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Aug 2019 | 25,000 | 0 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 14 Aug 2019 | 25,000 | 152,935 (0%) | 0% | 7.2 | 180,250 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 32.10 per share. | 23 Jul 2019 | 33,333 | 295,326 (0%) | 0% | 32.1 | 1,069,989 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jul 2019 | 33,333 | 100,000 | - | - | Common Stock | |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jul 2019 | 33,334 | 132,333 | - | - | Common Stock | |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jul 2019 | 33,333 | 166,667 | - | - | Common Stock | |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 29.65 per share. | 23 Jul 2019 | 33,333 | 295,326 (0%) | 0% | 29.6 | 988,323 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 23 Jul 2019 | 33,333 | 328,659 (0%) | 0% | 7.2 | 240,331 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 32.11 per share. | 23 Jul 2019 | 33,334 | 295,326 (0%) | 0% | 32.1 | 1,070,355 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 23 Jul 2019 | 33,334 | 328,660 (0%) | 0% | 7.2 | 240,338 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 23 Jul 2019 | 33,333 | 328,659 (0%) | 0% | 7.2 | 240,331 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 34.57 per share. | 10 Jul 2019 | 25,000 | 127,935 (0%) | 0% | 34.6 | 864,250 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jul 2019 | 25,000 | 25,000 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 10 Jul 2019 | 25,000 | 152,935 (0%) | 0% | 7.2 | 180,250 | Common Stock |
| Lutz Lingnau | None | Sale of securities on an exchange or to another person at price $ 34.63 per share. | 08 Jul 2019 | 10,000 | 23,200 (0%) | 0% | 34.6 | 346,300 | Common Stock |
| Lutz Lingnau | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jul 2019 | 10,000 | 0 | - | - | Stock Option | |
| Lutz Lingnau | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.24 per share. | 08 Jul 2019 | 10,000 | 33,200 (0%) | 0% | 9.2 | 92,400 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 33.71 per share. | 17 Jun 2019 | 25,000 | 127,935 (0%) | 0% | 33.7 | 842,750 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Jun 2019 | 25,000 | 50,000 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 17 Jun 2019 | 25,000 | 152,935 (0%) | 0% | 7.2 | 180,250 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 May 2019 | 33,333 | 66,667 | - | - | Common Stock | |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 May 2019 | 33,333 | 0 | - | - | Common Stock | |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 May 2019 | 33,334 | 33,333 | - | - | Common Stock | |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 32.69 per share. | 21 May 2019 | 33,333 | 295,326 (0%) | 0% | 32.7 | 1,089,656 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 21 May 2019 | 33,333 | 328,659 (0%) | 0% | 7.2 | 240,331 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 33.38 per share. | 21 May 2019 | 33,334 | 295,326 (0%) | 0% | 33.4 | 1,112,689 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 21 May 2019 | 33,334 | 328,660 (0%) | 0% | 7.2 | 240,338 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 32.93 per share. | 21 May 2019 | 33,333 | 295,326 (0%) | 0% | 32.9 | 1,097,656 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 21 May 2019 | 33,333 | 328,659 (0%) | 0% | 7.2 | 240,331 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 31.37 per share. | 16 May 2019 | 3,767 | 127,935 (0%) | 0% | 31.4 | 118,171 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 31.37 per share. | 16 May 2019 | 13,383 | 295,326 (0%) | 0% | 31.4 | 419,825 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 31.37 per share. | 16 May 2019 | 1,928 | 164,463 (0%) | 0% | 31.4 | 60,481 | Common Stock |
| Maninder Hora | SVP Pharma Dev & Mfg Ops | Sale of securities on an exchange or to another person at price $ 31.37 per share. | 16 May 2019 | 2,449 | 94,694 (0%) | 0% | 31.4 | 76,825 | Common Stock |
| John Nicholson | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 31.37 per share. | 16 May 2019 | 4,077 | 166,578 (0%) | 0% | 31.4 | 127,895 | Common Stock |
| Stephen K. Doberstein | SVP & Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 31.37 per share. | 16 May 2019 | 3,461 | 95,913 (0%) | 0% | 31.4 | 108,572 | Common Stock |
| R. Scott Greer | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2019 | 10,000 | 0 | - | - | Stock Option | |
| R. Scott Greer | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.14 per share. | 08 Mar 2019 | 10,000 | 145,083 (0%) | 0% | 5.1 | 51,400 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 42.39 per share. | 19 Feb 2019 | 3,592 | 131,702 (0%) | 0% | 42.4 | 152,265 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 19 Feb 2019 | 33,333 | 350,924 (0%) | 0% | 7.2 | 240,331 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Feb 2019 | 33,333 | 166,667 | - | - | Common Stock | |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Feb 2019 | 33,333 | 100,000 | - | - | Common Stock | |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Feb 2019 | 33,334 | 133,333 | - | - | Common Stock | |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 41.01 per share. | 19 Feb 2019 | 33,333 | 308,709 (0%) | 0% | 41.0 | 1,366,986 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 19 Feb 2019 | 33,333 | 342,042 (0%) | 0% | 7.2 | 240,331 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 43.20 per share. | 19 Feb 2019 | 33,334 | 308,709 (0%) | 0% | 43.2 | 1,440,029 | Common Stock |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.21 per share. | 19 Feb 2019 | 33,334 | 342,043 (0%) | 0% | 7.2 | 240,338 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 42.39 per share. | 19 Feb 2019 | 8,882 | 308,709 (0%) | 0% | 42.4 | 376,508 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 42.32 per share. | 19 Feb 2019 | 33,333 | 317,591 (0%) | 0% | 42.3 | 1,410,653 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 42.39 per share. | 19 Feb 2019 | 1,808 | 166,391 (0%) | 0% | 42.4 | 76,641 | Common Stock |
| Maninder Hora | SVP Pharma Dev & Mfg Ops | Sale of securities on an exchange or to another person at price $ 42.39 per share. | 19 Feb 2019 | 2,386 | 97,143 (0%) | 0% | 42.4 | 101,143 | Common Stock |
| John Nicholson | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 42.39 per share. | 19 Feb 2019 | 3,822 | 170,655 (0%) | 0% | 42.4 | 162,015 | Common Stock |
| Stephen K. Doberstein | SVP & Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 42.39 per share. | 19 Feb 2019 | 3,310 | 99,374 (0%) | 0% | 42.4 | 140,311 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Feb 2019 | 16,119 | 0 | - | - | Stock Option | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.69 per share. | 04 Feb 2019 | 16,119 | 184,318 (0%) | 0% | 10.7 | 172,312 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 42.16 per share. | 04 Feb 2019 | 16,119 | 168,199 (0%) | 0% | 42.2 | 679,577 | Common Stock |
| John Nicholson | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Jan 2019 | 63,000 | 0 | - | - | Stock Option | |
| John Nicholson | SVP & Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.69 per share. | 28 Jan 2019 | 63,000 | 237,477 (0%) | 0% | 10.7 | 673,470 | Common Stock |
| John Nicholson | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 42.82 per share. | 28 Jan 2019 | 63,000 | 174,477 (0%) | 0% | 42.8 | 2,697,660 | Common Stock |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2018 | 28,750 | 135,294 (0%) | 0% | 0 | Common Stock | |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2018 | 58,100 | 58,100 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2018 | 68,450 | 317,591 (0%) | 0% | 0 | Common Stock | |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2018 | 138,350 | 138,350 | - | - | Stock Option | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2018 | 10,950 | 168,199 (0%) | 0% | 0 | Common Stock | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2018 | 22,150 | 22,150 | - | - | Stock Option | |
| Maninder Hora | SVP Pharma Dev & Mfg Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2018 | 18,500 | 99,529 (0%) | 0% | 0 | Common Stock | |
| Maninder Hora | SVP Pharma Dev & Mfg Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2018 | 37,350 | 37,350 | - | - | Stock Option | |
| Stephen K. Doberstein | SVP & Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2018 | 23,950 | 102,684 (0%) | 0% | 0 | Common Stock | |
| Stephen K. Doberstein | SVP & Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Dec 2018 | 48,400 | 48,400 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 38.25 per share. | 16 Nov 2018 | 6,515 | 106,544 (0%) | 0% | 38.3 | 249,199 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 38.25 per share. | 16 Nov 2018 | 15,326 | 249,141 (0%) | 0% | 38.3 | 586,220 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 38.25 per share. | 16 Nov 2018 | 4,016 | 157,249 (0%) | 0% | 38.3 | 153,612 | Common Stock |
| Maninder Hora | SVP Pharma Dev & Mfg Ops | Sale of securities on an exchange or to another person at price $ 38.25 per share. | 16 Nov 2018 | 4,694 | 81,029 (0%) | 0% | 38.3 | 179,546 | Common Stock |
| John Nicholson | SVP & Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 38.25 per share. | 16 Nov 2018 | 5,982 | 174,477 (0%) | 0% | 38.3 | 228,812 | Common Stock |
| Stephen K. Doberstein | SVP & Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 38.25 per share. | 16 Nov 2018 | 4,524 | 78,734 (0%) | 0% | 38.3 | 173,043 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Nov 2018 | 90,000 | 161,265 (0%) | 0% | 0 | Common Stock | |
| Christopher A. Kuebler | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 4,750 | 45,250 (0%) | 0% | 0 | Common Stock | |
| Christopher A. Kuebler | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 9,500 | 9,500 | - | - | Stock Option | |
| Karin Eastham | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 8,500 | 8,500 (0%) | 0% | 0 | Common Stock | |
| Karin Eastham | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 17,000 | 17,000 | - | - | Stock Option | |
| R. Scott Greer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 9,500 | 9,500 | - | - | Stock Option | |
| R. Scott Greer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 4,750 | 135,083 (0%) | 0% | 0 | Common Stock | |
| Robert B. Chess | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 9,500 | 9,500 | - | - | Stock Option | |
| Robert B. Chess | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 4,750 | 274,473 (0%) | 0% | 0 | Common Stock | |
| Roy A. Whitfield | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 9,500 | 9,500 | - | - | Stock Option | |
| Roy A. Whitfield | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 4,750 | 181,750 (0%) | 0% | 0 | Common Stock | |
| Lutz Lingnau | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 4,750 | 23,200 (0%) | 0% | 0 | Common Stock | |
| Lutz Lingnau | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 9,500 | 9,500 | - | - | Stock Option | |
| Jeffrey R. Ajer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 4,750 | 20,500 (0%) | 0% | 0 | Common Stock | |
| Jeffrey R. Ajer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Sep 2018 | 9,500 | 9,500 | - | - | Stock Option | |
| Lutz Lingnau | None | Sale of securities on an exchange or to another person at price $ 56.98 per share. | 20 Sep 2018 | 9,000 | 18,450 (0%) | 0% | 57.0 | 512,820 | Common Stock |
| Jeffrey R. Ajer | None | Sale of securities on an exchange or to another person at price $ 56.76 per share. | 20 Sep 2018 | 6,750 | 15,750 (0%) | 0% | 56.8 | 383,130 | Common Stock |
| Robert B. Chess | None | Sale of securities on an exchange or to another person at price $ 56.81 per share. | 19 Sep 2018 | 4,500 | 269,723 (0%) | 0% | 56.8 | 255,645 | Common Stock |
| R. Scott Greer | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Sep 2018 | 10,000 | 10,000 | - | - | Stock Option | |
| R. Scott Greer | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 5.14 per share. | 04 Sep 2018 | 10,000 | 140,333 (0%) | 0% | 5.1 | 51,400 | Common Stock |
| R. Scott Greer | None | Sale of securities on an exchange or to another person at price $ 67.39 per share. | 04 Sep 2018 | 10,000 | 130,333 (0%) | 0% | 67.4 | 673,900 | Common Stock |
| Dennis L. Winger | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.26 per share. | 17 Aug 2018 | 15,000 | 57,750 (0%) | 0% | 14.3 | 213,900 | Common Stock |
| Dennis L. Winger | None | Sale of securities on an exchange or to another person at price $ 60.30 per share. | 17 Aug 2018 | 15,000 | 42,750 (0%) | 0% | 60.3 | 904,500 | Common Stock |
| Dennis L. Winger | None | Sale of securities on an exchange or to another person at price $ 59.62 per share. | 17 Aug 2018 | 15,000 | 42,750 (0%) | 0% | 59.6 | 894,300 | Common Stock |
| Dennis L. Winger | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 14.26 per share. | 17 Aug 2018 | 15,000 | 57,750 (0%) | 0% | 14.3 | 213,900 | Common Stock |
| Dennis L. Winger | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2018 | 15,000 | 15,000 | - | - | Stock Option | |
| Dennis L. Winger | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2018 | 15,000 | 0 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2018 | 65,000 | 65,000 | - | - | Stock Option | |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2018 | 26,000 | 121,266 (0%) | 0% | 0 | Common Stock | |
| Gil M. Labrucherie | SVP & Chief Financial Officer | Sale or transfer of securities back to the company at price $ 58.40 per share. | 15 Aug 2018 | 8,207 | 113,059 (0%) | 0% | 58.4 | 479,289 | Common Stock |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2018 | 26,250 | 26,250 | - | - | Stock Option | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2018 | 10,400 | 76,148 (0%) | 0% | 0 | Common Stock | |
| Jillian B. Thomsen | SVP & Chief Accounting Officer | Sale or transfer of securities back to the company at price $ 58.40 per share. | 15 Aug 2018 | 4,883 | 71,265 (0%) | 0% | 58.4 | 285,167 | Common Stock |
| Maninder Hora | SVP Pharma Dev & Mfg Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2018 | 37,500 | 37,500 | - | - | Stock Option | |
| Maninder Hora | SVP Pharma Dev & Mfg Ops | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2018 | 15,000 | 91,669 (0%) | 0% | 0 | Common Stock | |
| Maninder Hora | SVP Pharma Dev & Mfg Ops | Sale or transfer of securities back to the company at price $ 58.40 per share. | 15 Aug 2018 | 5,946 | 85,723 (0%) | 0% | 58.4 | 347,246 | Common Stock |
| John Nicholson | SVP & Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2018 | 65,000 | 65,000 | - | - | Stock Option | |
| John Nicholson | SVP & Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2018 | 26,000 | 188,596 (0%) | 0% | 0 | Common Stock | |
| John Nicholson | SVP & Chief Operating Officer | Sale or transfer of securities back to the company at price $ 58.40 per share. | 15 Aug 2018 | 8,137 | 180,459 (0%) | 0% | 58.4 | 475,201 | Common Stock |
| Stephen K. Doberstein | SVP & Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2018 | 65,000 | 65,000 | - | - | Stock Option | |
| Stephen K. Doberstein | SVP & Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2018 | 26,000 | 89,959 (0%) | 0% | 0 | Common Stock | |
| Stephen K. Doberstein | SVP & Chief Scientific Officer | Sale or transfer of securities back to the company at price $ 58.40 per share. | 15 Aug 2018 | 6,701 | 83,258 (0%) | 0% | 58.4 | 391,338 | Common Stock |
| Howard W. Robin | Director, President & CEO | Sale or transfer of securities back to the company at price $ 58.40 per share. | 14 Aug 2018 | 20,389 | 264,467 (0%) | 0% | 58.4 | 1,190,718 | Common Stock |
| Howard W. Robin | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Aug 2018 | 151,250 | 151,250 | - | - | Stock Option | |
| Howard W. Robin | Director, President & CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Aug 2018 | 40,000 | 0 | - | - | Stock Option |